Abstract
We studies the effect of pazufloxacin (PZFX), a new oral pyridone-carboxylic acid derivative, on the serum concentration of theophylline (TP) in 5 healthy male volunteers.
In advance, TP alone was given orally for four days at a daily dose of 400mg b. i. d., then the serum samples were obtained as a control. From the 5th day of TP administration, concomitant administration of PZFX at a daily dose of 200mg t.i.d. was started. Blood was drawn on the 3rd and 5th days of the concomitant administration, and the serum concentrations of TP were compared with that of control.
On the 3rd and 5th days of the concomitant administration, no significant difference were observed in any pharmacokinetic parameters such as AUC, Cmax and C1TB of TP. No objective nor subjective side effect was observed throughout the experimental period.
According to above results, we concluded that PZFX is safe drug when it is administered concomitantly with TP.
