Abstract
The in vitro and in vivo postantibiotic effects (PAEs) of pazufloxacin (PZFX), a new synthetic antimicrobial agent, were compared with those of ofloxacin (OFLX). After 1-hour exposure of Staphylococcus aureus Smith to 2 MICs of PZFX and OFLX, the in vitro PAEs were 1.75 and 1.95 hours, respectively. Similarly, the in vitro PAEs of PZFX and OFLX against Klebsiella pneumoniae BK were 1.35 and 0.85 hours, respectively. The PAEs of PZFX and OFLX at 4 MICs were 2.08 and 1.95 hours, respectively. Higher drug concentrations prolonged the PAEs.
PZFX was subcutaneously injected, at a dose of 4 mg/kg of body weight, to the back of mice infected with K. pneumoniae BK. The in vivo PAE and the maximum bactericidal activity (ΔLog10 CFU/Thigh) of PZFX were 2.2 hours and 2.24, respectively, slightly superior to the 1.2 hours and 1.67, respectively, of OFLX.
