Pharmacokinetics of ritipenem acoxil

Abstract

Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method.
The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T_1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC_0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.