1995 Volume 43 Issue Supplement4 Pages 143-151
Basic and clinical study on cefluprenam (CFLP) in the field of surgical infections, especially intraabdominal infections and skin and soft tissue infections were conducted.The activities of CFLP against recent clinical isolates of MSSA, Enterococcus faecalis and Pseudomonas aeruginosa were superior to those of ceftazidime, cefpirome, cefotaxime, cefuzonam, cefepime, cefoperazone and flomoxef.Against Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Serratia marcescens and Citrobacter freundii, CFLP was as active as these reference drugs.Sixteen targeted diseases consisted of peritonitis, cholangitis, wound infection, periproctal abscess, lymphangitis, phlegmon and pneumonia.The severity of infections was severe for 8, moderate for 7 and mild for 1 case.Clinical efficacy judged by presiding doctors in 16 cases was excellent for 2, good for 11, fair for 2, poor for 1 case, showing the efficacy rate of 81.3%. Causative organisms were detected bacteriologically in 15 of 16 cases.Clinical efficacy by isolated organisms in 15 cases was excellent for 2, good for 10 and fair for 2, poor for 1 case, showing the efficacy rate of 80.0%.Bacteriological responses in 15 cases were eradication for 5, replacement for 6, partial eradication for 3 and unchanged for 1 case, with the eradication rate of 73.3%.Five of 7 cases showing no response to preceding chemotherapies responsed to CFLP regimen.No adverse drug reaction was noted.Abnormal laboratory change was noted in 1 case showing eosinophilia.
