Abstract
The pharmacokinetics of azithromycin (AZM) in patients with renal failure were investigated by dividing patients into a mild group (Group I: 50<creatinine clearance [Ccr]≤70ml/min), a moderate group (Group II: 30<Ccr≤50ml/min), and a severe group (Group III: Ccr≤30ml/min), based on Ccr values.
1) The times when the serum concentration reached its maximal level (Tmax) in Groups I, II and III were 2.0, 2.4 and 2.0 hours, respectively, after a single oral 500mg administration of AZM. Maximal serum concentrations (Cmax) in these groups were 0.557, 0.538 and 0.582μg/ml, respectively. The respective half times (T1/2) were 34.1, 33.8 and 29.9 hours. There were no significant differences in any of the parameters calculated from the serum concentrations among the three groups.
2) The rates of AZM recovery from urine, 72 hours after administration, in the above groups were 4.48, 4.51 and 2.87%, respectively, showing a significant difference between Groups II and III.
