Report of a case of advanced double cancer of the esophagus and stomach successfully treated by combination chemotherapy with cisplatin, etoposide and 5-fluorouracil (PEF)

Abstract

A 60-year-old man with double cancer of the esophagus and stomach and bilateral lung metastases and cervical lymph node metastasis was treated by combination chemotherapy with cisplatin, etoposide and 5-fluorouracil (PEF). Cisplatin (50 mg/m²) and etoposide (100 mg/m²) were administered by simultaneous drip infusion 8 times at two-week intervals, and 5-fluorouracil (300 mg/m²/day) was infused continuously for 105 days. Not only the cervical and lung metastases, but the primary lesions in the esophagus and stomach were markedly decreased in size after the second dose of cisplatin and etoposide, and the effects lasted for over 7 months. Mild and transient anorexia, hair loss and leucopenia (3, 300/mm³) were experienced during therapy.