1997 Volume 45 Issue 11 Pages 951-954
A 79-year-old man with chronic bronchitis was suffered from repeated exacerbations of Haemophilus influenzae infection, and frequent fluoroquinolone treatments were applied. The bacterial strains isolated from the early episodes were reported to be susceptible to ofloxacin or other antibiotics by routine disk susceptibility test, and frequent fluoroquinolone treatment was given. However, oral cephalosporine treatment did not achieve complete remission or bacterial eradication after this episode. Finally, he was treated by double-blind comparative trial of AM-1155 and levofloxacin, which failed to eradicate H. influenzae. The strains isolated from his sputum during and after the therapy were resistant to ofloxacin. The MICs of these strains against various fluoroquinolones were 2-32μg/ml, which were considered to be high enough to cause treatment failures.
