1997 Volume 45 Issue 2 Pages 69-77
The drug susceptiblity pattern and frequency of detection of β-lactamases-producing strains were investigated in probable causative organisms among clinical isolates obtained in our laboratory in 1995 mainly cases of from community-acquired pneumonia and aspiration pneumonia. The results are summarized as follows;
1. The detection frequency of β-lactamase-producing strains were high against methicillinresistant Staphylococcus aureus (MRSA) of S. aureus subsp. aureus, penicillin-resistant Streptococcus pneumoniae (PRSP) of S. pneumoniae, Haemophilus influenzae, and Moraxella subgenus Branhamella catarrhlis, and multiple drug resistant strains of Pseudomonas aeruginosa were a large. When the drug susceptiblity pattern was antibacterial spectrum of Empiric therapy against mainly community-acquired pneumonia, sulbactam/ampicillin (SBT/ABPC) appeared to be high effective. Because, the MIC90 of SBT/ABPC was low against S. pneumoniae including PRSP, β-lactamase-producing H. influenzae and M.(B.) catarrhalis.
2. The drug susceptiblity pattern of microaerophilus gram-positive cocci (Streptococcus milleri group, Gemella morbillorum), Peptostreptococcus spp., Bacteroides spp. and Prevotella spp. suggested that the detection frequency of cephem (CEP)-, erythromycin (EM)-and clindamycin (CLDM)-resistant strains was high against in the S. milleri group, Peptostreptococcus spp. and Bacteroides spp., and that the detection on ferquency of CEP-and EM-resistant strains were high among G. morbillorum and Prevotella spp. The detection frequency of II -lactamase-producing strains was 80.0 % among Bacteroides spp. and Prevotella spp., and the MIC90 of SBT/ABPC and sulbactam/cefoperazone was lowest among Bacterioides spp. and Prevotella spp. When the MIC90 of the test drugs against those bacterial species made the drug susceptiblity pattern, the distribution of SBT/ABPC was low.
