Clinical study of penetration of flomoxef into serum and pancreatic juice

Abstract

To evaluate the organ penetration of flomoxef (FMOX), we investigated its concentration in serum and pancreatic juice of 14 patients after intravenous injection of a 2 g FMOX. The results obtained were as follows:
1. The peak concentration of FMOX in serum was 134.3±32.1 μg/ml and occured 30 minutes after administration.
2. The peak concentration of FMOX in pancreatic juice was 4.69±4.12 μg/ml and occured 30 minutes after administration.
3. High concentrations of FMOX in pancreatic juice were observed even at 2 hours after administration.
4. Bacteria isorated from drained pancreatic juice were mainly Escherichia coli and Klebsiella pneumoniae for which the MIC of FMOX was less than 0.1 μg/ml. Thus FMOX was affective against these bacteria in pancreatic juice.
5. Rates of penetration of FMOX into pancreata affected by fibrosis were lower than into pan-creata without fibrosis.