Abstract
The antimicrobial activities of arbekacin (ABK) or flomoxef (FMOX) at sub-and above-MICs against clinical strain of methicillin-resistant Staphylococcus aureus (MRSA) during the postantibiotic phase PA-phase induced by FMOX or ABK were examined. Antimicrobial activities were determined growth suppression (postantibiotic sub-MIC effect: PA SME) at sub-MICs, and bactericidal activity at sub- and above-MICs. During the PA-phase induced by FMOX, growth suppression and bactericidal activity of ABK were enhanced at sub and above-MICs, compared with the non PA-phase. On the other hand, during the PA-phase induced by ABK, but bactericidal activity were declined at above-MICs compared with non PA-phase. These suggest that not only enhancement of growth suppression and bactericidal activity at sub-MICs, but decline of bactericidal activity at above-MICs during PA-phase were factors of combination effect of ABK and FMOX against MRSA.
