Susceptibility testing isepamicin for gram-negative rod resistance to β-lactams isolated from blood

Abstract

We studied susceptibility testing isepamicin (ISP) of aminoglycosides and antibacterials for gramnegative rod resistance to β-lactams isolated from blood. MICs of 14 antibacterial agents, aminoglycosides, and β-lactams against gram-negative rods. Bacterial strains were 50 clinical isolates, 9 of Escherichia coli, 10 of Proteus mirabilis, 3 of Providencia stuartii, 3 of Enterobacter aerogenes, 9 of Enterobacter cloacae, 10 of Serratia marcescens, 3 of Pseudomonas aeruginosa, 1 of Klebsiella oxytoca, 1 of Morganella morganii, and 1 of Citrobacter freundii. MICs of ISP ranged from 1 to≥256μg/mL. MIC₅₀ was 4μg/mL and MIC. was 16μg/mL. Our results suggest that ISP is an effective antibacterial agent against β-lactam resistance from blood.