Abstract
A 63-year-old man admitted for persistent cough and sputum was found in detailed examinations to have advanced lung adenocarcinoma (T4 N3 M1, stage IV). One course of combination chemotherapy of cisplatin and paclitaxel was administered. Since grade III nausea developed, they were switched to a combination of carboplatin and TXL, which was administered for 2 coureses. All subjective symptoms were resolved and image findings, particularly ground-glass opacities spreading over the bilateral lung fields, completely disappeared. Cancer recurred about 1.5 months later while he was followed up as an outpatient. None of subsequent chemotherapy regimens were effective. This phenomenon, suggesting tolerance or cross-tolerance of drugs, is now being studied and is considered an important issue in chemotherapy for non-small-cell lung carcinoma.
