In vivo efficacy of biapenem against mouse pneumonia infection caused by MexAB-OprM overproducing Pseudomonas aeruginosa

Abstract

In vivo efficacy of biapenem (BIPM) against mouse pseudomonal pneumonia infection was compared to that of imipenem/cilastatin (IPM/CS) and meropenem (MEPM).All carbapenems showed high therapeutic efficacy against sensitive P.aeruginosa. BIPM efficacy against the MexAB-OprM overproducing strain was superior to IPM/CS and MEPM.Therapeutic response of BIPM against MexAB-OprM overproducing and MexCD-OprJ producing strain was superior to MEPM and similar to IPM/CS.BIPM effectiveness was compared to IPM/CS and MEPM using a mouse model infection with different inoculum size.In 10⁵ order CFU/lung, therapeutic efficacy of BIPM, IPM/CS, and MEPM was comparable, but in 10⁶ order CFU/lung, BIPM showed higher efficacy than IPM/CS or MEPM.