Abstract
We determined the antibacterial activities of 19 antibiotics, including 5 carbapenems, against 124 strains isolated from the inpatients and outpatients with complicated urinary tract infections (c-UTIs) who were treated at Urology Clinic, Kagoshima University Medical Center between January 2004 and December 2005. The MICs were determined using the agar dilution method. Nine strains of Staphylococcus aureus, 13 strains of Enterococcus faecalis, 41 strains of Escherichia coli, 17 strains of Klebsiella spp., and 44 strains of Pseudomonas aeruginosa were examined.Vancomycin and teicoplanin were strongly active against the clinical isolates of Gram-positive bacteria, additionally, arbekacin was active against S. aureus, and ampicillin was active against E. faecalis.Imipenem and panipenem showed good activity against E. faecalis, but methicillin-resistant S. aureus were resistant to all the carbapenems. As for the clinical isolates of Gram-negative bacteria, carbapenems were active against almost all strains of Enterobacteriaceae, however fluoroquinolone (FQN)-resistant E. coli have been increasing since 2000. The percentage of FQN-resistant E. coli was about 25% in this study. Against the clinical isolates of P. aeruginosa, the MIC90 of the carbapenems were 16-32mg/L and the resistance rate has been increasing. Six strains of multi-drug resistant P. aeruginosa were isolated. The resistance rates of urinary isolates to antimicrobials has been increasing, however, carbapenems retain their outstanding position as the antibacterial drugs of empiric choice for severe c-UTI patients, if they are used appropriately.
