Abstract
The use of antibiotics to Pseudomonas aeruginosa was studied in relation to the antimicrobial susceptibility using 3, 002 clinical isolates of P. aeruginosa obtained from patients of Public Fujioka General Hospital between 2002 and 2006. The high proportion of isolates showed susceptibility to piperacillin (PIPC), amikacin (AMK) and levofloxacin (LVFX), and the number of strains with resistance to the tree antibiotics did not change during this period. Use of carbapenems, especially imipenem (IPM) was decreased year by year. However, the number of resistance strains did not change.Use of carbapenems was not associated with the drug susceptibility of the isolates. The patterns of the susceptibility to IPM were different from that to meropenem (MEPM). IPM-resistant strains were susceptible to other antibiotics, while MEPM-resistant strains were resistant to other antibiotics.Especially, all of 20 isolates which were resistant to IPM and susceptible to MEPM were susceptible to PIPC, ceftazidime (CAZ), aztreonam (AZT) and AMK. Since the permeabilitychannels of P. aeruginosa are different for IPM and MEPM and the efflux systems are associated only with MEPM, the cross-resistance of P. aeruginosa to MEPM and other antibiotics should be carefully considered in treatment of infectious disease caused P. aeruginosa.
