Spectroscopic analysis of Indomethacin-Saccarin mixed system using Singular Value Decomposition

Abstract

In previous studies, we obtained pH profile of pH indicators and physicochemical parameters of time-dependent crystallization of drug in solid dispersion by applying chemometric methods using singular value decomposition to Ultraviolet–visible spectroscopy, Terahertz time-domain spectroscopy, and X-ray Powder Diffraction. Pharmaceutical cocrystals are new solid forms with the potential to enhance pharmaceutical properties. To elucidate the enhancement of bioavailability of Indomethacin by formation of cocrystal with Saccarin, we applied our methods to Indomethacin-Saccarin mixed system.