構造活性相関とSF物語

寺田 弘

doi:10.11545/ciqs.tokusi.0.JK01.0

24th Symposium on Chemical Information and Computer Sciences

DOI https://doi.org/10.11545/ciqs.tokusi.0.JK01.0

Conference information

Host: Division of Chemical Information and Computer Science, The Chemical Society of Japan

Co-host: The Pharmaceutical Society of Japan, Japan Society for Bioscience, Biotechnology, and Agrochemistry, The Japan Society for Analytical Chemistry, Japan Chemistry Program Exchange, Japanese Society for Information and Systems in Education (Approaval)

Plenary Lecture

SF and my personal structure-activity relationships

*Hiroshi Terada

Author information

Keywords: SF6847, uncoupling, dynamic structure of molecules, structure activity relationship, transporter

CONFERENCE PROCEEDINGS FREE ACCESS

Pages JK01

Details

Abstract

This paper deals with the action of SF6847, which shows scientific fiction-like very potent uncoupling activity of oxidative phosphorylation in mitochondria. SF6847 was found to act as a catalyst due to its protonophoric activity, supporting the establishment of chemi-osomotic energy transduction theory of oxidative phosphorylation. Structural basis of the efficient protonophoric action of SF6847 is discussed.

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