Development of Chemical Safety Database

Abstract

Numerous chemicals have been produced by mankind. But recently their effects on global environment are serious matter. Numerous accidents due to chemicals happened everywhere. Among chemicals available in market, quite few are ascertained on safety. Reliable data on chemical safety are few and sparse. So, it is necessary to construct a database which collect reliable data on chemical safety. Animal test to get data on chemical safety takes much cost and period. So it is impossible to get safety data on every unascertained chemicals by animal test. Here a computer prediction by QSAR is meaningful for screening. Several prediction systems by QSAR have been developed. But the performances of existing systems are all low. Considering these situations, we are developing a computer-aided evaluation system on chemical safety by structure-activity relationship named CSD. It consists of two subsystems, one is a database subsystem which contains reliable hazard data on numerous chemical substances, and another is a prediction subsystem which evaluates hazard or safety on known or unknown chemical substance by quantitative structure-activity relationship.