Congenital Anomalies Associated with Isolated Cleft Palate

Abstract

We experienced 183 cases of isolated cleft palate (59 in males and 124 in females) between1968 and 2003 in The Jikei University School of Medicine. The average age of the patients was 9.9 months (4 days to 11 years) at the first examination. Congenital anomalies were associated with cleft palate in 57 patients (31.1%; 21 males and 36 females). Of these 57 cases, 43 (13 males and 30 females) occurred in both the hard and soft palate and 18 (8 males and 10 females) in the soft palate. No congenital anomalies were found in the submucous cleft palate, tongue tie was found in 7 cases, inguinal hernia in 5 cases, congenital heart disease in 8 cases, anomalies of extremities in 12 cases, and mental retardation in 11 cases. Robin sequence and Apert syndrome were each found in 11 cases.