Abstract
There have been many epidemiologic and experimental studies on the relation between hematological changes during pregnancy and fetal development, but there is no study concerning hematological changes related to cleft lip and/or palate. So, this study was aimed to find out the relation between hematological changes during pregnancy and clefting in the mouse.
Findings are as follows:
1. Hematological data of non-pregnant A/J mouse are; WBC 7.3±2.32x103/mm3, RBC 1045±58.1x104/mm3, Hb 17.3±0.78 g/dl, Ht 48.3±3.33%, MCV 46.2±1.21 //3, MCH 16.6±0.59, u, ug, M CHC 35.9±1.66%.
2. Compared with the non-pregnant control, RBC, Hb and Ht dropped appreciably in pregnant A/J mouse.
3. A/J mothers which had cleft embryos seemed to be more anemic than those of no cleft embryos during pregnancy.
4. Cleft palate may be induced by anemia, which will influence corpuscular constants, in the 10th day of gestation of A/J mouse.
