Abstract
C3H/HeN MTV+ mice and some other strains of mice are infected with MMTV (mouse-mammary-tumor-virus), and the transcription of this virus is significantly stimulated by glucocorticoid. So, this study was aimed to find out the role of MMTV in glucocorticoidinduced cleft palate in mice.
Findings are as follows:
1. C3H/HeN MTV+ mice were found to be more susceptible to glucocorticoid-induced cleft palate than C3H/HeN MTV- mice which are free of MMTV.
2. C3H/HeN MTV-, BALB/c and C57BL/10 mice, which were inoculated with MMTV from C3H/HeN MTV+ mice, were found to become susceptible to glucocorticoidinduced cleft palate.
3. MMTV was found to be able to influence susceptibility to glucocorticoid-induced cleft palate in mice.
