Abstract
From 1974 to 1982, we have performed primary repairs on 126 pati ents with bilateral cleft lip. In these patients,11 pedigrees have two affected children, involving at least one of bilateral cleft lip in same siblings. We have studied statistical analyses on these patients, based upon birth order, type of cleft and sex. The results are as follows:
1. There are more cases in the group, where the older sibling has unilateral cleft lip and the younger sibling has bilateral cleft lip than in the group with the reversed conbination (i. e. older sibling has bilateral cleft lip and young er one has unilateral cleft lip) (p<0.05).
2. There is no relation between birth order and sex in this study.
3. In the group, where older sibling has a unilateral cleft lip and the younger one has bilateral cleft lip;
a) there is good relationship between birth order and sex (p<0.10).
b) there are more cases with male-to-male combination (p<0.05).
Analyses on 2532 cases of cleft lip and palate have been report ed by Sanui in1962. In this report, we have seen the similar finding in 10 pedigress just like our cases. We have also analysed on the total 21 cases from our study and Sanui's report. The results were similar to our previous case study. On the other hand, statistical analyses of Sanui'ss cases alone did not produce the results that we obtained in our cases alone.
