Clinical Neuropsychopharmacology and Therapeutics
Online ISSN : 1884-8826
ISSN-L : 1884-8826
Case Report
Agranulocytosis with combination of paliperidone and clozapine: a case report
Sara DehanovMário SantosPatrícia GonçalvesTeresa Maia Correia
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2020 Volume 11 Pages 79-84


Antipsychotics are the most common psychotropic drugs associated with blood dyscrasias, and clozapine is the most notably implicated when agranulocytosis occurs, although other antipsychotic agents can cause this serious side effect at different levels of risk. We present the case of a 26-year-old man with a treatment-resistant schizophrenia who developed agranulocytosis while under treatment with the combination of paliperidone and clozapine. We discuss the individual and combined implications of both antipsychotics in the development of agranulocytosis and the importance of haematological monitoring for combined antipsychotic treatment in general, and not only when clozapine is used. To the authors' knowledge this is the first report of agranulocytosis with the combination of clozapine and paliperidone.

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© 2020 The Japanese Society of Clinical Neuropsychopharmacology
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