Clinical Neuropsychopharmacology and Therapeutics
Online ISSN : 1884-8826
ISSN-L : 1884-8826
Case Report
A case of a depressive patient with alcohol and nicotine dependence successfully treated with sertraline
Wakako Umene-NakanoReiji YoshimuraAsuka KatsukiJun Nakamura
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2011 Volume 2 Pages 24-26


Multiple studies have reported that tobacco smoking, alcohol use, and depression are interrelated. Here we report a case of a 54-year old male depressive patient with comorbid alcohol and nicotine dependence who was successfully treated with sertraline. After treatment with sertraline, the patient's plasma levels of MHPG and HVA were increased, but his serum BDNF level was. Sertraline exhibits more potent efficacy than other SSRIs in inhibiting dopamine reuptake. This unique effect of sertraline on catecholamine systems contributed to the successful outcome in this case.

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© 2011 The Japanese Society of Clinical Neuropsychopharmacology
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