Clinical Neuropsychopharmacology and Therapeutics
Online ISSN : 1884-8826
ISSN-L : 1884-8826
Original Contribution
Effect of treatment with atypical drugs for 6 months on brain levels of N-acetyl aspartate or serum levels of brain-derived neurotrophic factor in early-stage first-episode schizophrenia - a preliminary study
Naoki GotoReiji YoshimuraShingo KakedaJoji NishimuraJunji MoriyaKenji HayashiHikaru HoriAtsuko Ikenouchi-SugitaWakako Umene-NakanoAsuka KatsukiKiyokazu AtakeYukunori KorogiJun Nakamura
Author information

2011 Volume 2 Pages 34-42


In the present study, we investigated the effects of atypical antipsychotic drugs on brain NAA and serum BDNF levels in early-stage first-episode schizophrenia patients. Sixteen (8 males, 8 females; mean age: 30 ± 11 yr) of 18 patients were followed for 6 months. All patients were treated with atypical antipsychotic drugs. No changes in NAA concentrations in the three regions were observed from before treatment to 6 months after atypical psychotic treatment. In addition, serum BDNF levels also did not change from before to 6 months after treatment. These preliminary results suggest that relatively short-term treatment with atypical antipsychotic drugs may be unlikely to alter brain NAA concentrations and serum BDNF levels in early-stage first-episode schizophrenia.

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© 2011 The Japanese Society of Clinical Neuropsychopharmacology
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