Effect of Menthol Oral Stimulation on Capsaicin-Induced Cough in Healthy Participants

Abstract

Background: Menthol is an ingredient with antitussive properties in over-the-counter medicines. However, only a few studies support the cough-relieving effects of these products. Therefore, we aimed to examine the cough-relieving effects of menthol. Methods: Baseline capsaicin cough sensitivity was measured in healthy adults on day one. Four weeks later, the menthol oral stimulation test was performed. Results: Forty-four individuals participated in this study. Median capsaicin threshold concentration of control and menthol were 7.81 μM and 15.63 μM, respectively. Cough thresholds were increased by oral menthol stimulation. Conclusions: Oral administration of menthol suppressed capsaicin cough sensitivity in healthy adults.