2. Development and Clinical Application of New ET-Kyoto Solution, an Extracellular Fluid Type Organ Preservation Solution Containing Trehalose and Vascular Endothelial Protective Agents

Abstract

Although organ transplantation is established as a therapeutic procedure for various terminal organ dysfunctions, there are many unsolved problems such as shortage of donors and primary graft failure. A more reliable organ preservation solution could resolve these problems. Therefore, we have developed new ET-Kyoto solution characterized by extracellular type ion composition, non-reducing disaccharide of trehalose, and vascular endothelial protective agents (dibutyryl cAMP, nitroglycerin, N-acetyl cysteine). We confirmed the superior efficiency of the solution in canine lung transplantation and have applied it to clinical lung transplantation at Kyoto University Hospital since April 2002.