Abstract
Preparation and evaluation procedures of amorphous drugs are reviewed. Amorphous drug as a pharmaceutical dosage form of poorly water-soluble drug has been investigated to improve the dissolution property in spite of the stability problem. Glass transition temperature (Tg) of the amorphous form is a good index to evaluate the stability of the drug during storage. As a recent advance in technology, many evaluation procedures have been developed to identify the amorphous state. Amorphous forms are possible to prepare by many methods, such as milling, supercooling, spray-drying and freeze-drying. Drug adsorption into porous material is also an effective way to make the amorphous form. Cefditroren pivoxil, chenodeoxycholic acid and thoxyphenylacetyltylosin (MAT) and the physicochemical properties are introduced as examples for the amorphous forms of drugs.
