CYTOLOGIA
Online ISSN : 1348-7019
Print ISSN : 0011-4545
Cytologia Focus
FISH Is in the Limelight Again As More Than a Cytogenetical Technique for Metaphase Chromosomes
Sachihiro Matsunaga
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JOURNALS OPEN ACCESS

2016 Volume 81 Issue 1 Pages 3-6

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Abstract

Fluorescent in situ hybridization (FISH) has been a powerful technique to reveal chromosomal loci and distribution of DNA sequences in metaphase chromosomes. Three-dimensional FISH (3D-FISH) has also revealed the chromosome territory of interphase chromosomes in the nucleus. Recently, 3D-FISH has played a supportive or complementary role to confirm the genome organization and topologically associated domains, which are provided by chromosome conformation capture techniques.

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© 2016 Japan Mendel Society, International Society of Cytology
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