Components of the Nuclear Pore Complex are Rising Stars in the Formation of a Subnuclear Platform of Chromatin Organization beyond Their Structural Role as a Nuclear Gate

Abstract

The nuclear pore complex is a multiprotein complex comprising approximately 30 different proteins called nucleoporins (Nups). Recent studies in yeast, animals, and plants have shown that the Nups bind to chromatin and interact with transcription factors, chromatin-remodeling factors, histone-modifying enzymes, and chromatin structural proteins, including the CCCTC-binding factor and cohesin. These findings suggest that the Nups provide a subnuclear platform for gene expression, chromatin organization, and DNA repair.