Differential Response of Cells of Mixed Population and of T-enriched Population to Concanavalin A, and Reconstitution of Lymphocyte Response by Phorbol Myristate Acetate or Interleukin 2

Abstract

The cells of T-enriched population did not respond to low dose of Con A, whereas low dose of Con A could induce proliferation of the cells of mixed population. The response of the cells of T-enriched population was reconstituted by PMA or purified IL-2 which was added at the time of Con A addition. IL-2 could promote IL-2R expression and proliferation of the cells stimulated with non-mitogenic dose of Con A. These results indicate that IL-2 in cooperation with low dose of Con A can activate the cells, and induce both IL-2R expression and proliferation.