Clastogenic Activity of Quinoline, Isoquinoline and Pyridine

Abstract

Clastogenic effects of quinoline, isoquinoline and pyridine, three closely related members of the heterocyclic group of compounds have been studied in root tip cells of Allium cepa. Each substance was tested over a wide dose range. The untreated controls rarely showed the presence of fragments All the three chemicals produced marked clastogenic activity and induced a significant increase in the frequency of chromosome breaks and exchanges.