Abstract
Chromosomal damage induced by two pesticides viz. phosphamidon and endosulfan employing in vivo chromosomal aberration bioassay in bone marrow cells of male albino mice of Lacca strain (Mus musculus) have been investigated. Different doses tested for phosphamidon (2.55, 2.98 and 3.40μg/g, b. wt.) and for endosulfan (1.75, 3.50 and 5.25μg/g, b. wt.) were injected intraperitoneally. The observations were recorded at time intervals of 1, 2, 5 and 10 days. Both clastogenic as well as physiological types of aberrations were induced by these pesticides. The clastogenic type aberrations induced by phosphamidon and endosulfan in the bone marrow cells of mice include chromosomal fragmentation, chromatid breaks, chromosomal and chromatid gaps, ring chromosomes, interchromatid exchanges, minutes and dicentric chromosomes. Physiological type of aberrations caused by both of these pesticides include centromeric associations, exchange configurations, bizarre configurations, shrinkage of chromosomes, stickiness and end to end associations. Generally, it was observed that the chromosomal aberrations are more at higher doses as compared to lower doses tested in the present investigations.
