Clastogenic Potential Testing of Some Hair Dye Components by the Bone Marrow Micronucleus Analysis

Abstract

Three types of commonly used hair dye components, 4-amino-2-ntirophenol; 1, 4-diamino-2-nitrobenzene and metaphenylene diamine were treated to male mice for detection of gross chromosomal abnormalities follwing the bone marrow micronucleus test. All the test compounds were found to be clastogenic. The study also addressed the high toxicities of nitrophenol, nitrobenzene and phenylenediamine dyes and immediated attention should be given arresting their application for environmental homoeostasis.