The Analysis of Genetic Aberration in Colorectal Cancer with Genomic Array Comparative Genomic Hybridization(CGH).

Abstract

We investigated the chromosome aberrations of colorectal cancer with Genomic Array CGH, and analyzed those relations to lymph node or distant metastasis. There were significant associations between the loss of 8p and the depth of cancer, between the gain of 7q and lymph node metastasis, and between the gain of 8q and liver metastasis, respectively. When we analyzed the chromosome aberrations of both primary and liver metastatic tumor, almost identical changes were found in each case. Genomic Array CGH, which enabled to express the characteristics of each cancer, may contribute to practice ‘ the tailor maid treatment' (personal therapy).