Simultaneous detection of multiple cytokines in septic-shock model mice.

Abstract

Hypercytokinemia and systemic inflammatory response syndrome (SIRS) is found in patients with shock due to sepsis. However complete set of cytokine profile as the hidden circumstances that led up to the case was not inquired. We measured 23-kind circulating cytokines simultaneously in virulent strain, Plasmodium bergheiinfected mice sera by suspension-array analysis. We had previously reported the induction of IL-18 production in malaria patients, as well as malaria-model mice. This report also discusses possible physiological roles of IL 18 induced by Plasmodium infection.