Cytometry Research
Online ISSN : 2424-0664
Print ISSN : 0916-6920
ISSN-L : 2424-0664
review
The effect of treatment for Myeloid derived suppressor cells in tumor bearing host
Tomoko TanakaKimihiro YamashitaDai OtsuboAkira ArimotoMasayasu NishiHiroshi HasegawaMasashi YamamotoShingo KanajiYoshiko MatsudaTaro OshikiriTakeru MatsudaYasuo SumiTetsu NakamuraSatoshi SuzukiYoshihiro Kakeji
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2016 Volume 26 Issue 2 Pages 27-31

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Abstract

Myeloid derived suppressor cells (MDSCs), a major player for tumor-induced immunosuppression, especially induce antigen-specific CD8-Tcell tolerance and contribute to tumor growth and progression. MDSCs represent a heterogeneous group of cells originated from the myeloid cells. MDSCs accumulate in tumor-bearing mice and cancer patients. Various drugs that directly target MDSCs can improve antitumor immune response. Recent studies have demonstrated MDSCs can be suppressed by certain chemotherapeutic agents, such as 5-Fluorouracil (5-FU), gemcitabin and docetaxel. We hypothesized that treatment by 5-FU or surgical resection of primary tumors would prevent lung metastasis formation by inhibiting MDSCs. These results indicate that early-phase administration of 5-FU and early-phase resection of the primary tumor may provide therapeutic values to prevent MDSC-mediated lung metastases in tumor-bearing host. The results of our study may give a clue to develop a new strategy to control malignant tumors by regulating tumorassociated immune responses. Furthermore, we reviewed current research on the MDSC-targeted therapy.

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