Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Feature articles “Molecular targeting therapy in cancer” Editor : Toshiharu Yamaguchi
Drug discovery from chemical genetics on histone deacetylase
Minoru Yoshida
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JOURNAL FREE ACCESS

2006 Volume 21 Issue 1 Pages 32-38

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Abstract
Histone deacetylase (HDAC) is a family of enzymes that was discovered as a regulator of chromatin structure and function by means of chemical genetics. It is increasingly drawing attention as a molecular target for cancer therapy, since HDAC has been linked to tumorigenesis and tumor angiogenesis, and its inhibitors induce cell cycle arrest, differentiation and apoptosis in a variety of cancer cells.
This review focuses on the recent advance of chemistry and biology of HDAC inhibitors.
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© 2006 Japan Society of Drug Delivery System
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