Abstract
A comprehensive and precise list of drug transporters has become available. Moreover, cDNA clones can be obtained easily through researchers, public resources or commercial providers. To date, substrate preferences and other functional characteristics of transporters can be studied by using in vitro expression systems. All information should be accumulated, integrated and utilized. Efficient organ-specific drug delivery should be feasible by appropriately modifying the chemical structure of drugs.
This review article was aimed to introduce recent success in delivery of drugs to target organs via transporters, and to discuss issues that should be considered to establish organ-specific drug delivery system.
