Abstract
This review summarizes studies on drug delivery system (DDS) utilizing sugar transporter. It has been reported intestinal absorption of various monosaccharide conjugates (glycosides) via Na+/glucose cotransporter (SGLT1). Transportability and recognizability of the glycosides by SGLT1 depend on types of sugar, glycoside linkage and aglycone. Therefore, glycosides should be classified by TRN classification for DDS development. Transportability of β-glucoside is the highest among glycosides. Monosaccharide conjugates such as β-glucoside should work as a prodrug, which can be transported by SGLT1. Moreover, disaccharide conjugates have potential as a pre-prodrug.
On the other hand, it has not been reported clear evidence for sugar transporter-mediated delivery of glycosides to brain and kidney.
