Abstract
We have developed two advanced nanotechnologies, NANOEGG® and NANOCUBETM. They are useful technologies for not only drug but also cosmetics. Today, we have long span of life because of advanced medical science. Therefore, anti-aging drugs, foods, and cosmetics strongly attract us. NANOEGG®-atRA, nanocapsuled all trans retinoic acid (atRA) with coated inorganic salts, showed enhanced pharmacological activity, compared with atRA as such. NANOEGG® methods could be applied to other cosmetic compounds.
The topical administration of lyotropic liquid crystal NANOCUBETM on stratum corneum rapidly broke down the lipid lamella structure which would be recognized as a wound without organ-change. This can activate a variety of biological processes. Using small angle X-ray scattering (SAXS) analysis, the response to the transient structural change of lipid was detected because it might result the diffusion of oil and/or water from NANOCUBETM liquid crystal towards lipid lamella phase. This method actually succeeded the improvement of photo-induced hyperpigmentation on human face.
These observations suggest that the structural change of lipid may stimulate to trigger recognition of a slight injury in the wound defense and repair response by homeostasis.
