Abstract
Recent alarming increases of drug resistant pathogens have been serious problems causing parallel increases of intractable cases in acute otitis media and rhinosinusitis among Japanese children. For developing effective antimicrobial treatments against such intractable bacterial infectious diseases, physician should pay much attention to appropriate selection of antibiotics and administrative routes concerning pharmacokinetics and pharmacodynamics (PK/PD) of antibiotics and attractive drug delivery systems (DDS).
In the current study, we investigated two types of newly developed controlled-release antibiotics for the treatment of experimental otitis media caused by nontypeable Haemophilus influenzae in chinchillas. The controlled-release antibiotics showed better bactericidal effect rather than systemic administration or topical use of antibiotics. The controlled-release antibiotics by use of DDS will be attractive new procedures for the antimicrobial treatment against intractable bacterial infections.
