Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Gene delivery into stem cells by modified adenovirus vectors
Kenji KawabataFuminori SakuraiHiroyuki Mizuguchi
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JOURNAL FREE ACCESS

2007 Volume 22 Issue 2 Pages 148-154

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Abstract
The application of adenovirus (Ad) vectors, which are widely used in gene therapy, depends on CAR (coxsackievirus and adenovirus receptor) expression on the cells. To overcome this problem, the capsid proteins of Ad vectors have been genetically modified. Here, we introduce several types of capsid-modified Ad vectors. Furthermore, we describe the application of capsid-modified Ad vectors into some kinds of stem cells for regenerative medicine.
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© 2007 Japan Society of Drug Delivery System
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