Recent progress in skin bioengineering technique and its application to percutaneous absorption

Abstract

Many noninvasive techniques to measure skin physiological properties have been developed in skin bioengineering field. They are measurement of water content of stratum corneum, skin surface contour, TEWL(transepidermal water loss), skin color, blood flow, sebum secretion rate and so on. In addition to above methods, recently, a few bio-microscopes which can examine the inside of the skin in vivo have been developed and applied to skin absorption of drugs. I describe in this paper the study on drug delivery using in vivo confocal Raman microscopy and multiphoton microscopy.