Abstract
Anticancer agents are rapidly absorbed into the circulation when given intraperitoneally in a form of aqueous solution. Therefore, it is difficult to maintain the drug concentration at a high level for a long time in peritoneal cavity. To overcome the difficulty, a lot of modification and improvement using DDS(drug delivery system) have been done. Additionally, recent investigation has revealed the mechanism of peritoneal metastasis and the drug distribution after administrated intraperitoneally. Based on the evidences, this article reviews DDS for intraperitoneal chemotherapy including recent advances.
