Abstract
The study aimed to devise a novel anticancer drug delivery system with targeting and a sustained release of the agent.
We used two different types of 70% deacetylated chitin as the drug carriers:namely, DAC-70 and DAC-70'. Cis-platinum(CDDP) and fluorouracil(5-FU) were applied as the model drugs. Targeting effect was evaluated by ex vivo adhesive force between each system and human colonic mucosa. Release profile of the anticancer drugs was examined in vitro. Each system prepared demonstrated a stronger visco-elasiticity comparing with that of the conventional drugs. Seventy percent of CDDP was gradually delivered from the DAC-70/ CDDP for 3 days, while the release from the DAC-70'/ CDDP was significantly slower. The DAC/ 5-FUs exhibited an initial bursting of the 5-FU.
We presume that the differences observed in the drug release were closely related with both the degradability of the carriers and interactions between each drug and vehicle. The studies suggested that the DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.
