Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Feature articles “Development of DDS for respiratory diseases” Editor : Shigeru Kohno
Pulmonary drug delivery systems for the treatment of tuberculosis
Hiroyuki Inagawa, Chie Kohchi, Gen-ichiro Soma, Makoto Matsumoto, Shuji Yamashita, Hiroshi Terada, Kimiko Makino
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Keywords: tuberculosis, pulmonary drug delivery system, PLGA, rifampicin, microsphere
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2008 Volume 23 Issue 4 Pages 474-480

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Abstract
As Asia has been suffered greatly from various infectious diseases, such as tuberculosis, AIDS and malaria, it is very important to establish the efficient drug delivery system(DDS) against these diseases. Tuberculosis is caused by Mycobacterium tuberculosis, AIDS is by human immunodeficiency virus (HIV) and malaria is by plasmodium. In this review article, DDS for the treatment of tuberculosis will be presented. Tubercle bacilli are phagocytosed by macrophages but are not digested. To overcome this problem, we have started with two strategies, 1) develop a dosage form/formulation of DDS making pathogens more easily to be phagocytosed by macrophages, 2) activate the phagocytotic capacity of pathogen -infected macrophages.
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© 2008 Japan Society of Drug Delivery System
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