Drug Delivery System
Online ISSN : 1881-2732
Print ISSN : 0913-5006
ISSN-L : 0913-5006
Feature articles “Drug discovery and DDS by using biomaterials” Editor : Hiroaki Okada
Development of a siRNA anticancer drug using sustained release microsphere injection
Takanori Kanazawa, Yuuki Takashima, Hiroaki Okada
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Keywords: small interfering RNA (siRNA), chemical modification, poly (DL-lactic/glycolic acid)(PLGA), sustained release microspheres, anti-tumor effect
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2008 Volume 23 Issue 5 Pages 544-552

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Abstract
In order to develop a siRNA drug, chemical modification and formulation of siRNA are required. We prepared long-term sustained release microspheres (msp) encapsulating siRNA with a cationic carrier. The siRNA msp achieved a persistent suppression of tumor growth in S-180 bearing mice.
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© 2008 Japan Society of Drug Delivery System
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