Abstract
Calorie restriction(CR) is the most interesting topic among the Japanese Society of Anti-Aging Medicine(JAAM) and The American Academy of Anti-Aging Medicine(A4M). This method up-regulates Sir-2(silent information regulator 2). Sir-2 is a crucial gene for longevity. Since the 1930s extensive scientific research has shown that CR diets improve health and extend life spans of nearly every species tested, including worms, spiders, rodents, dogs, cows and monkeys. We believe it is likely that people who carefully adopt a CR diet will see similar results.
Sir-2 of yeast is a heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. SIRT1 promotes fat mobilization in white adipocytes by peroxisome proliferator-activated receptor response(PPAR)-gamma. This finding suggests sirtulin interact various nuclear factors. According to our results, CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor response element(PPRE). Therefore, sirtuin may transactivate PPAR target genes via the PPRE. Further study should be done.
Another topic is the drug as the target organ of small intestine. Small intestine has many various unknown mechanisms. Further study reveal anti-aging drug by the modulation of small intestine function as drug delivery system(DDS).
