Abstract
Prostaglandin E1(PGE1)is one of the lipid mediators and has potent biological activities such as inhibitor of platelet aggregation, and vasodilator. Lipid microspheres consist of egg yolk lecithin and soybean oil (o/w emulsion), have a diameter of 200∼300 nm, and preferentially accumulate in vascular lesion and inflammatory site. Therefore, PGE1 incorporated in lipid microsphere (Lipo PGE1 preparation) was efficiently delivered to target lesion, and more effective in human being as well as animal models. Lipo PGE1 preparation was introduced onto the Japanese market in 1988, and now applicable in both Korea and China, and has contributed to improving the condition of patients with arteriosclerosis obliterans, peripheral vascular diseases, and so on.
